This medical study examines the clinical characteristics and management of penile intraepithelial neoplasia (PeIN), a rare precancerous condition, based on a large cohort of 345 patients.
The authors distinguish between undifferentiated PeIN, which is strongly linked to human papillomavirus (HPV), and differentiated PeIN, which is associated with lichen sclerosus (LSc). While topical therapies and cryotherapy are utilized, the research highlights that surgical intervention, particularly circumcision, serves as the primary treatment for most cases.
The findings demonstrate that specialized multidisciplinary care leads to excellent outcomes, with only a small percentage of patients progressing to invasive cancer. Furthermore, the source advocates for HPV vaccination and smoking cessation as vital components of a comprehensive preventative strategy.
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Citation:
Kravvas G, Ge L, Ng J, Shim TN, Doiron PR, Watchorn R, Kentley J, Panou E, Dinneen M, Freeman A, Jameson C, Haider A, Francis N, Minhas S, Alnajjar H, Muneer A, Bunker CB. The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature. J Dermatolog Treat. 2022 Mar;33(2):1047-1062.